Dr. Mohamad Hafizi Abu Bakar

Position: Program Chaiperson, Bioprocess Technology Division, School of Industrial Technology, USM

Areas of Expertise:

• Mammalian cell & tissue culture technology
• Metabolomics biomarkers using multi-omics approaches (systems biology)
• Mechanistic target of pharmacologically-active compounds against inflammation, obesity, insulin resistance and type 2 diabetes
• Nutrient sensing and metabolic signaling integration
• Functional biomaterial and bioceramics - cellular mechanistic interactions
• Bioprocessing in cultivated meat technology

Dr. Mohamad Hafizi Abu Bakar is a Program Chairperson, Principal Investigator and Senior Lecturer at the Bioprocess Technology Division, School of Industrial Technology, Universiti Sains Malaysia (USM). He obtained the First Class Honor in Bachelor of Biomedical Science (Hons) from International Islamic University Malaysia (IIUM) in July 2012. Subsequently, he successfully completed his PhD study in Bioprocess Engineering at the Universiti Teknologi Malaysia (UTM) in December 2015 under supervision of Prof. Dr. Mohamad Roji Sarmidi. During UTM 56th Convocation Ceremony, he received the 'Best Postgraduate Student Award' (PhD category) in Bioprocess Engineering.

My Research Profile:

ORCID: orcid.org/0000-0001-8064-695X

ResearcherID: O-4454-2016

Author ID (Scopus): Scopus ID

ResearchGate: https://www.researchgate.net/profile/Mohamad_Hafizi_Abu_Bakar

Mendeley: Profile

Google scholar: https://bit.ly/3f7sanV

My QR code - ORCID

Related SDGs

My research interests are devoted, but are not limited to, tissue-cellular crosstalk towards elucidation of pathophysiological mechanisms of metabolic diseases and their associations with inflammation and mitochondrial dysfunction. Also, I'm currently investigating the therapeutics target of pharmacologically-active compounds derived from plant natural products and microalgae against numerous metabolic diseases.

Research areas:

• Cellular-tissues crosstlak of metabolic signaling in metabolic diseases

• Bioprocessing in cultivated meat technology

• Mitochondria, metabolomics, and lipodomic: identification of circulating biomarkers in obesity and type 2 diabetes subjects using multi-integrated omics approach.

• Establishment of cellular disease models for metabolic diseases

• Mechanistic targets of pharmacologically active plant-derived natural products on cellular/animal models with metabolic diseases.

• Bioprospecting of high value secondary metabolites from microalgae biomass extracts.

 

Associate Editorial Board Member
Bentham Science
Current Signal Transduction Therapy (Scopus indexed)
ISSN: 2212-389X (Online)
ISSN: 1574-3624 (Print)

 {tab=Teaching}

Teaching subjects:

• IBA206 - Practical in Cell and Tissue Culture Technology (3 units) – current (Course Coordinator)
• IBG215 – Fundamental of Stem Cell Technology (3 units) – current (Course Coordinator)
• IBG207 - Cell and Tissue Culture Technology (3 units) - 2019/2020 - Current (Course Coordinator)
• IBA404 - Bioprocess Technology Research Project (16 units) – Current
• IMK105 – Biochemistry (2 units) - 2018/2019 
• IMK227 - Biochemistry (3 units) - 2020/2021 - Current
• IBK312 - Issues in Bioprocess Technology (3 units) -Current
• IBG111 - Industrial Microbiology (3 units) - 2017/2018
• IBK315 - Bioinformatics (2 units) - 2020/2021 - Current (Course Coordinator)
• IBG205 - DNA & Metabolites Technology (3 units) - Current
• TCE502 – Nutrition in Health and Disease (3 unit) – 2017/2018 (Master Mixed Mode - IPPT, USM )

 

Undergraduate

Completed as a Main Supervisor:

• Nur Afiqah Che Musa – Bachelor of Technology (Bioprocess)
  Title: In vitro α- glucosidase inhibitory effect and phytochemical content of Labisia pumila extracts
  Session: 2016-2017
  
  
• Rasyidah Abu Bakar – Bachelor of Technology (Bioprocess)
  Title: α-amylase inhibitory activity of ethanol extracts from Labisia pumila
  Session: 2016-2017
  
  
• Phua Yoong Hui - Bachelor of Technology (Bioprocess)
  Title: Kinetic of α-amylase and α-glucosidase inhibitory potential of stilbene derivatives: An in vitro study
  Year: 2017/2018

• Nur Amalina Adzlan - Bachelor of Technology (Bioprocess)
  Title: Inhibition of carbohydrate hydrolyzing enzymes, antioxidant activity and polyphenolic content of Murraya koenigii extracts
  Year: 2017/2018

• Lee Pui Yee - Bachelor of Technology (Bioprocess)
  Title: In vitro anti-hyperglycaemic activity of fractionated Endiandra kingiana leave extracts
  Year: 2017/2018

• Yip Lee Mei - Bachelor of Technology (Bioprocess)
  Title: Kinetic of In vitro inhibitory effect of Beilschmiedia and Endiandra species extracts on pancreatic lipase activity
  Year: 2018/2019

• Tay Yen Nee - Bachelor of Technology (Bioprocess)
  Title: Inhibition of carbohydrate hydrolysing enzymes, antioxidant activity and polyphenolic content of Beilschmiedia species extracts
  Year: 2018/2019

Postgraduate

Main supervisor: 

1) Mohamad Shamil Faris Bin Mohamad Khalid, 2019 - Current, PhD candidate

2) Nor Shafiqah Binti Nor Shahril, 2020 - Current, MSc candidate

3) Sharifah binti Mohammad, 2019, - Current PhD candidate

4) WANG XIAOJUAN, 2022 - Current, PhD candidate

5) WANG HAICHAO, 2021 - Current, PhD candidate

Co-supervisor: 

1) Leh Hui Eng, 2019 - Current, MSc candidate - Main SV: Dr. Lee Lai Kuan (Completed)

2) Ramizah Binti Kamaludin, 2020 - Current, Msc candidate 

3) Beauty Akter, 2020 - Current, PhD candidate - Main SV: Dr. Rabeta Mohd Salleh

4) Nur Anis Binti Mohd Ariffin, 2020 - Current, MSc candidate - Main SV: Dr. Lee Lai Kuan

5) Noor Syarafana Binti Firouz, 2020 - Current, MSc candidate - Main SV: Dr. THIRUVENTHAN A/L KARUNAKARAN

6) NORISHA BINTI MOKHTAR, 2020 - Current, MSc candidate - Main SV: Dr. THIRUVENTHAN A/L KARUNAKARAN

7) AHMAD ALIF DANIAL BIN ZAILAN, 2020 - Current, MSc candidate - Main SV: Dr. THIRUVENTHAN A/L KARUNAKARAN

8) AHMED HAFEDH MOHAMMED MOHAMMED, 2020 - Current, PhD candidate - Main SV: Dr. KHAIRUL ANUAR BIN SHARIFF

9) NUR ZULAIKHA BINTI MOHAMAD ZAIDI, 2021 - Current, MSc candidate - Main SV: Dr. KHAIRUL ANUAR BIN SHARIFF

10) AL JAF MUHAMMAD TAHIR MUHAMMAD, 2021 - Current, PhD candidate - Main SV: Dr. MOHAMAD NURUL AZMI BIN MOHAMAD TAIB

 

Research Grants

National:

• Title: Prognostic Markers for Mitochondrial Dysfunctions in Type 2 Diabetes (2012-2014)
  Source: Exploratory Research Grant Scheme (ERGS), Ministry of Education Malaysia
  Role: Research Associate
  Amount: MYR 174K

• Title: Metabolic Mechanism of Reactive Oxygen Species induced Inflammation in Type 2 Diabetes (2013-2015)
  Source: Fundamental Research Grant Scheme (FRGS), Ministry of Education Malaysia
  Role: Member
  Amount: MYR 150K

• Title: Quantitative Hormone Interaction Mapping for Insulin Resistance (2014-2016)
  Source: Fundamental Research Grant Scheme (FRGS), Ministry of Education Malaysia
  Role: Member
  Amount: MYR 102K

• Title: Symbiotic Cube Cultivation System for Sustainable Farming (2014-2016)
  Source: Prototype Research Grant Scheme (PRGS), Ministry of Education Malaysia
  Role: Member
  Amount: MYR 150K

• Title: Cellular Mechanism of Celastrol on Palmitate-mediated Insulin Resistance (Dec 2016- Nov 2018)
  Source: Universiti Sains Malaysia Short Term Grant
  Role: Principle Investigator
  Amount: MYR 30K

• Title: Biosynthesis of Chlorella sp. and Tetraselmis suecica carbohydrate polymer in carbon dioxide (CO2) rich fermentation condition (Dec 2017- Nov 2019)
  Source: Universiti Sains Malaysia Research University Grant (RUi)
  Role: Member
  Amount: MYR 81K

• Title: Development of Aqueous Polymer-Phase Impregnated Adsorbent System for Purification of Biotechnological Products (Esterase and Lipase) (March 2018- March 2020)
  Source: Universiti Sains Malaysia Short Term Grant
  Role: Member
  Amount: MYR 32K

• Title: Isolation, Characterization and Biological Evaluation of Endiandric Acids Isolated from Genus Beilschmiedia and Endiandra (Lauraceae Family) as Potential Antidiabetic Agents (August 2018- July 2020)
  Source: Universiti Sains Malaysia Research University Grant (RUi)
  Role: Member
  Amount: MYR 70K

• Title: Antimicrobial mechanism of action and structure-function of bacteriocin-cellular target complex from locally isolated lactic acid bacteria towards inhibition of multidrug-resistant bacterial pathogens (January 2019- December 2020)
  Source: Fundamental Research Grant Scheme (FRGS), Ministry of Education Malaysia
  Role: Member
  Amount: MYR 124K

• Title: Metabolic mechanism of inter-tissue crosstalk for excess nutrient flux in the biofluids of Type 2 Diabetes (T2D) individuals using an integrated multi-omics approach (September 2019- August 2021)
  Source: Fundamental Research Grant Scheme (FRGS), Ministry of Education Malaysia
  Role: Principal Investigator
  Amount: MYR 150K

• Title: The mechanistic approach of in vitro and in vivo activities of ethanolic extract and cyclic polyketides from Endiandra kingiana (Lauraceae) as potential anti-diabetic agents (September 2019- August 2021)
  Source: Fundamental Research Grant Scheme (FRGS), Ministry of Education Malaysia
  Role: Member
  Amount: MYR 142K

• Title: Unravelling mechanistic crosstalk between immunometabolic regulation and metabolic pathway reorganization induced by celastrol in adipocyte-macrophage co-culture systems (January 2020- December 2021)
  Source: Universiti Sains Malaysia Individual Research University (RUI) Grant
  Role: Principal Investigator
  Amount: MYR 65K

•  Title: Repolarization of M1 Macrophages in Breast Cancer Microenvironment by Using Mesenchymal Stem Cells (January 2020- December 2022)
  Source: Universiti Sains Malaysia Individual Research University (RUI) Grant
  Role: Member
  Amount: MYR 60K

International: 

Title: In vitro study of celastrol as a novel potential therapeutic target in fatty acid-induced obesity and insulin resistance: Unraveling the mechanism of action (December 2018- June 2020)
Source: The World of Academy Sciences (TWAS)- Joint Research International Grant
Role: Principal Investigator
Amount: USD 5000

Research Publication

Journal paper publications:

1. Mohamad Hafizi Abu Bakar*, Mohamad Roji Sarmidi, Cheng Kian Kai, Hasniza Zaman Huri and Harisun Yaakob. (2014). Amelioration of Mitochondrial Dysfunction-induced Insulin Resistance in Differentiated 3T3-L1 Adipocytes via Inhibition of NF-κB Pathways. International Journal of Molecular Sciences. 15(12), 22227-22257. Q2 Ranking. Impact Factor: 3.687-ISI/Scopus Indexed.

2. Mohamad Hafizi Abu Bakar*, Cheng Kian Kai, Wan Najihah Wan Hassan, Mohamad Roji Sarmidi, Harisun Yaakob and Hasniza Zaman Huri. (2015). Mitochondrial Dysfunction as A Central Event for Mechanisms Underlying Insulin Resistance: The Roles of Long Chain Fatty Acid. Diabetes/ Metabolism Research and Review. 31(5), 453-475. Q1 Ranking. Impact Factor: 3.904-ISI/Scopus Indexed.

3. Mohamad Hafizi Abu Bakar*, Mohamad Roji Sarmidi, Kian Kai Cheng, Abid Ali Khan, Lee Suan Chua, Hasniza Zaman Huri, Harisun Yaakob. (2015). Metabolomics – The Complementary Field in Systems Biology: A Review on Obesity and Type 2 Diabetes. Molecular BioSystems. 11(7), 1742-1774. DOI: 10.1039/C5MB00158G. Q2 Ranking. Impact Factor: 3.210-ISI/Scopus Indexed.

4. Mohamad Hafizi Abu Bakar*, Kian-Kai Cheng, Mohamad Roji Sarmidi, Harisun Yaakob, Hasniza Zaman Huri. (2015). Celastrol Protects against Antimycin A-Induced Insulin Resistance in Human Skeletal Muscle Cells. Molecules; 20(5):8242-8269. DOI: 10.3390/molecules20058242. Q2 Ranking. Impact Factor: 3.098-ISI/ Scopus Indexed.

5. Mohamad Hafizi Abu Bakar*, Wan Najihah Wan Hassan, Mohamad Roji Sarmidi, Harisun Yaakob. (2015). Mitochondrial Dysfunction Enhanced Lipolysis and Intracellular Lipid Accumulation in 3T3-L1 Adipocytes. International Journal of Pharma Medicine and Biological Sciences. 4(1):65-69.

6. Mohamad Hafizi Abu Bakar*, Kian-Kai Cheng, Mohamad Roji Sarmidi, Harisun Yaakob, Hasniza Zaman Huri. (2015).JNK Signaling Pathway is required for Mitochondrial Dysfunction-induced Insulin Resistance in WRL-68 Human Liver Cells. Diabetes Technology & Therapeutics. Volume 17 (1), A154-A155. DOI:10.1089/dia.2015.1525. Q3 Ranking. Impact Factor: 2.921-ISI/Scopus Indexed.

7. Mohamad Hafizi Abu Bakar*, Kian-Kai Cheng, Mohamad Roji Sarmidi, Harisun Yaakob, Hasniza Zaman Huri. (2015). Mitochondrial Dysfunction Induces Insulin Resistance in Differentiated 3T3-L1 Adipocytes via NF-κB Activation Pathways. 64 (1). Diabetes®. DOI: 10.2337/db15-2815-284. Q1 Ranking. Impact Factor: 8.474-ISI/Scopus Indexed.

8. Mohamad Hafizi Abu Bakar*, Mohamad Roji Sarmidi, Joo Shun Tan, Mohamad Norisham Mohamad Rosdi. (2017). Celastrol attenuates mitochondrial dysfunction and inflammation in palmitate-mediated insulin resistance in C3A hepatocytes. European Journal of Pharmacology. 799:73-83. Q2 Ranking. DOI: 10.1016/j.ejphar.2017.01.043. Impact Factor: 3.040-ISI/Scopus Indexed.

9. Nur Fazrin Husna Abdul Aziz, Sahar Abbasiliasi, Hui Suan Ng, Pongsathon Phapugrangkul, Mohamad Hafizi Abu Bakar, Yew Joon Tam, Joo Shun Tan. (2017). Purification of β-mannanase derived from Bacillus subtilis ATCC 11774 using ionic liquid as adjuvant in aqueous two-phase system. Journal of Chromatography B, 1055–1056:104 -112. DOI: 10.1016/j.jchromb.2017.04.029.Q2 Ranking. Impact Factor: 2.687-ISI/Scopus Indexed.

10. Mohamad Hafizi Abu Bakar*, Hasniza Zaman Huri and Nany Hairunisa. (2017). Alterations of cultured myotubes and fasting plasma metabolite profiles related to mitochondrial dysfunction in Type 2 diabetes subjects. Free Radical Biology and Medicine. 108 (1): S24. DOI: 10.1016/j.freeradbiomed.2017.04.104. Q1 Ranking. Impact Factor: 6.020-ISI/Scopus Indexed.

11. Mohamad Hafizi Abu Bakar* and Joo Shun Tan. (2017). Improvement of mitochondrial function by celastrol in palmitate-treated C2C12 myotubes via activation of PI3K-Akt signaling pathway. Biomedicine & Pharmacotherapy, 93: 903-912. DOI: 10.1016/j.biopha.2017.07.021. Q2 Ranking. Impact Factor: 3.457-ISI/Scopus Indexed.

12. Mohamad Hafizi Abu Bakar* and Mohamad Roji Sarmidi. (2017). Association of cultured myotubes and fasting plasma metabolite profiles with mitochondrial dysfunction in Type 2 diabetes subjects. Molecular Biosystems. 13: 1838-1853. DOI: 10.1039/C7MB00333A. Q2 Ranking. Impact Factor: 3.210-ISI/Scopus Indexed.

13. Mohamad Norisham Mohamad Rosdi, Shahkila Mohd Arif, Mohamad Hafizi Abu Bakar, Siti Aisyah Razali, Razauden Mohamed Zulkifli and Harisun Ya’akob. (2018). Molecular docking studies of bioactive compounds from Annona muricata Linn as potential inhibitors for Bcl-2, Bcl-w and Mcl-1 antiapoptotic proteins. Apoptosis. 23 (1): 27-40. DOI: 10.1007/s10495-017-1434-7. Q2 Ranking. Impact Factor: 3.967-ISI/Scopus Indexed.

14. Mohamad Hafizi Abu Bakar*, Nany Hairunisa and Hasniza Zaman Huri. (2018). Reduced mitochondrial DNA content in lymphocytes is associated with insulin resistance and inflammation in patients with impaired fasting glucose. Clinical and Experimental Medicine. 18(3): 373-382. DOI: 10.1007/s10238-018-0495-4. Q2 Ranking. Impact Factor: 2.919-ISI/Scopus Indexed.

15. Mohamad Hafizi Abu Bakar* (2018). Leukotriene B4 mediates vascular oxidative stress and mitochondrial dysfunction in human aortic endothelial cells. Free Radical Biology and Medicine. 120 (1): S137-S138. DOI: 10.1016/j.freeradbiomed.2018.04.453. Q1 Ranking. Impact Factor: 6.020-ISI/Scopus Indexed.

16. Joo Shun Tan, Sahar Abbasiliasi, Arbakariya B. Ariff, Hui Suan Ng, Mohamad Hafizi Abu Bakar and Yin Hui Chow (2018). Extractive purification of recombinant thermostable lipase from fermentation broth of Escherichia coli using an aqueous polyethylene glycol impregnated resin system. 3 Biotech. 8 (6): 288. DOI: 10.1007/s13205-018-1295-y. Q3 Ranking. Impact Factor: 1.786-ISI/Scopus Indexed.

17. Mohamad Hafizi Abu Bakar*, Mohamad Nurul Azmi, Khairul Anuar Shariff, Joo Shun Tan (2019). Withaferin A protects against high-fat diet–induced obesity via attenuation of oxidative stress, inflammation, and insulin resistance. Applied Biochemistry and Biotechnology. 188: 241–259. DOI: 10.1007/s12010-018-2920-2. Q2 Ranking. Impact Factor: 2.140-ISI/Scopus Indexed.

18. Mohammad M. Ibrahim, Mahmoud Al-Refai, Mohamad Nurul Azmi, Hasnah Osman, Mohamad Hafizi Abu Bakar, Armin Geyer (2019). Synthesis, characterization and cytotoxicity of new nicotinonitriles and their furo[2,3-b] pyridine derivatives. Journal of the Iranian Chemical Society. 16: 715–722. DOI: 10.1007/s13738-018-1549-y. Q3 Ranking. Impact Factor: 1.742-ISI/Scopus Indexed.

19. Joo Shun Tan, Pongsathon Phapugrangkul, Chee Keong Lee, Zee-Wei Lai, Mohamad Hafizi Abu Bakar, Paramasivam Murugan (2019). Banana frond juice as novel fermentation substrate for bioethanol production by Saccharomyces cerevisiae. Biocatalysis and Agricultural Biotechnology 21: 101293. DOI: 10.1016/j.bcab.2019.101293. ISI/Scopus indexed.

20. Mahmoud Al-Refai, Mohammad M. Ibrahim, Mohamad Nurul Azmi, Hasnah Osman, Mohamad Hafizi Abu Bakar and Armin Geyer.The Synthesis, Characterization, Cytotoxic Activity Assessment and Structure–Activity Relationship of 4-Aryl-6-(2,5-dichlorothiophen-3-yl)-2-methoxypyridine-3-carbonitriles (2019). Molecules 24 (22); 4072. DOI: 10.3390/molecules24224072. Q2 Ranking. Impact Factor: 3.060 - ISI/Scopus Indexed.

21. Yen Nee Tay, Mohamad Hafizi Abu Bakar*, Mohamad Nurul Azmi, Nur Amirah Saad, Khalijah Awang, Marc Litaudon, Mohd Asyraf Kassim (2020). Inhibition of Carbohydrate Hydrolysing Enzymes, Antioxidant Activity and Polyphenolic Content of Beilschmiedia Species Extracts. IOP Conference Series : Materials Science and Engineering, 716: 012007. DOI: 10.1088/1757-899x/716/1/012007. Scopus indexed.

22. Husnul Hanani Soib, Hassan Fahmi Ismail, Fitrien Husin, Mohamad Hafizi Abu Bakar, Harisun Yaakob and Mohamad Roji Sarmidi (2020). Bioassay-Guided Different Extraction Techniques of Carica papaya (Linn.) Leaves on In Vitro Wound-Healing Activities. Molecules, 25 (3): 517. DOI: 10.3390/molecules25030517. ISI/Scopus indexed.

24. Mohd Asyraf Kassim, M F I M Adnan, Kean Meng Tan, Mohamad Hafizi Abu Bakar, Japareng Lalung and Mohd Shamzi Mohamed (2020). Carbonic anhydrase (CA) activity by Chlorella sp. in immobilised matrix under carbon dioxide rich cultivation condition. IOP Conference Series : Materials Science and Engineering, 716: 012015. DOI: 10.1088/1757-899X/716/1/012015. Scopus indexed.

25. Haifaa’ Auni Mohammad Zaki, Khairul Anuar Shariff, Mohamad Hafizi Abu Bakar and Mohamad Nurul Azmi (2020). Effect of different granular size on the properties of porous β-tricalcium phosphate foam granular cements. Key Engineering Materials, 829: 23-27. DOI: 10.4028/www.scientific.net/KEM.829.23. Scopus indexed.

26. Mohamad Hafizi Abu Bakar*, Pui Yee Lee, Mohamad Nurul Azmi, Nurul Syifa’ Lotfiamir, Mohamad Shamil Faris Mohamad, Nor Shafiqah Nor Shahril, Khairul Anuar Shariff, Harisun Ya'akob, Khalijah Awang, Marc Litaudon (2020). In vitro anti-hyperglycemic, antioxidant activities and intestinal glucose uptake evaluation of Endiandra kingiana extracts. Biocatalysis and Agricultural Biotechnology, 25: 101594. DOI: 10.1016/j.bcab.2020.101594. ISI/Scopus indexed.

27. Thet Thet Swe, Khairul Anuar Shariff, Hasmaliza Mohamad, Kunio Ishikawa, Koichiro Hayashi, Mohamad Hafizi Abu Bakar (2020). Behavioural response of cells and bacteria on single and multiple doped Sr and Ag S53P4 sol-gel bioglass. Ceramics International. (Accepted - In press -correction). DOI: 10.1016/j.ceramint.2020.04.094. Q1 Ranking. Impact Factor: 3.45 - ISI/Scopus Indexed.

28. Joo Shun Tan , Sahar Abbasiliasi, Arbakariya Ariff, Paramasivam Murugan, Mohamad Hafizi Abu Bakar, Hui Suan Ng.Polymer impregnation in porous glass beads to induce bioseparation of β-mannanase from fermentation broth of Proteus vulgaris (2020). Minerva Biotecnologica 32 (2): 43 - 51. DOI: 10.23736/S1120-4826.20.02605-1. Q4 Ranking. Impact Factor: 0.596 - ISI/Scopus Indexed.

29. Mohamad Hafizi Abu Bakar*, Khairul Anuar Shariff, Joo Shun Tan, Lai Kuan Lee. Celastrol attenuates inflammatory responses in adipose tissues and improves skeletal muscle mitochondrial functions in high fat diet-induced obese rats via upregulation of AMPK/SIRT1 signaling pathways (2020). European Journal of Pharmacology 883 (In Press). DOI: 10.1016/j.ejphar.2020.173371. Q2 Ranking. Impact Factor: 3.276 – ISI/Scopus indexed.

30. Mohd Asyraf Kassim, Tan Kean Meng, Noor Aziah Serri, Siti Baidurah Yusoff, Nur Artikah Muhammad Shahrin, Khok Yong Seng, Mohamad Hafizi Abu Bakar, Lee Chee Keong. Chapter 2 - Sustainable Biorefinery Concept for Industrial Bioprocessing (2020). Biorefinery Production Technologies for
Chemicals and Energy. DOI: 10.1002/9781119593065.ch2. Page: 15-53

31. Beauty Akter, Rabeta Mohd Salleh, Mohamad Hafizi Abu Bakar. Synbiotic efficacy as therapeutic approach in human disease: a review (2021). Pertanika Journal of Tropical Agricultural Science, 44 (1): 69-82. DOI: http://dx.doi.org/10.47836/pjtas.44.1.04. Scopus indexed.

32. Mohamad Nurul Azmi, Nur Amirah Saad, Mohamad Hafizi Abu Bakar, Mohammad Tasyriq Che Omar, Ahmad Nazif Aziz, Habibah A Wahab, Sadia Siddiq, M Iqbal Choudhary, Marc Litaudon, Khalijah Awang. Cyclic Polyketides with α-Glucosidase Inhibitory Activity from Endiandra kingiana Gamble and Molecular Docking Study (2021). Records of Natural Products (In Press). DOI: http://doi.org/10.25135/rnp.227.20.11.1889. Scopus indexed.

33. Lim Jun Wei, Khairul Anuar Shariff, Syed Abdul Momin, Mohamad Hafizi Abu Bakar, Arief Cahyanto. Self-setting β-tricalcium phosphate granular cement at physiological body condition: effect of citric acid concentration as an inhibitor(2021) – In Press. Journal of the Australian Ceramic Society. Q2 Ranking. Impact Factor: 1.307. ISI/Scopus indexed.

Note:
*as a corresponding author

Academic Conference/Proceedings/Meeting Abstracts:

• Oral Presenter for Biochemistry Session in International Conference of Biomedical Engineering and Technology 2014 (ICBET 2014), 12th – 14th of March 2014, Penang, Malaysia. Title: Mitochondrial Dysfunction induced Lipolysis and Intracellular Lipid Accumulation in 3T3-L1 Adipocytes.

• Poster Presenter in Cell Symposia: Systems Approach to Metabolic Diseases 2014 (CMET 2014), 1st – 3rd of October 2014, Chicago, Illinois, USA. Title: Potential Metabolomics Markers for Mitochondrial Dysfunction in Type 2 Diabetes.

• Poster Presenter in Association's 75th Scientific Sessions. 5th – 9th of June 2015. MA, Boston, USA. Title: Mitochondrial Dysfunction Induces Insulin Resistance in Differentiated 3T3-L1 Adipocytes via NF-κB Activation Pathways. 64(Supp 1). Published in Diabetes®. DOI: 10.2337/db15-2815-284. Impact Factor: 8.474-ISI/Scopus Indexed.

• Oral Presenter in 8th International Conference on Advanced Technologies & Treatments for Diabetes 2015. 18th – 21st of February 2015. Paris, France. Title: JNK Signaling Pathway is required for Mitochondrial Dysfunction-induced Insulin Resistance in WRL-68 Human Liver Cells. Published in Diabetes Technology & Therapeutics. Volume 17, Supplement 1, A154-A155.DOI:10.1089/dia.2015.1525. Impact Factor: 2.29-ISI/Scopus Indexed.

• Oral Presenter in International Conference on Natural Products 2017 (ICNP2017). March 15-16 2017. Swiss Garden Beach Resort, Damai Laut, Perak, Malaysia. Title: Protective effects of celastrol on palmitate-mediated insulin resistance in human myotubes by restoring mitochondrial function.

• Poster Presenter in OCC World Congress and Annual SFRR-E Conference 2017 Metabolic Stress and Redox Regulation Berlin, Germany 21-23 June 2017. Title: Alterations of cultured myotubes and fasting plasma metabolite profiles related to mitochondrial dysfunction in Type 2 diabetes subjects.

MY CONTACT INFORMATION

Dr. Mohamad Hafizi Abu Bakar
Program Chairperson
Senior Lecturer/ Principal Investigator

Room A304, Level 3
Bioprocess Technology Divison
School of Industrial Technology
Universiti Sains Malaysia
11800 Penang
MALAYSIA

Email: mhafizi88@usm.my

Phone: +604-6535213

Fax: +604-6536375